KMID : 0043320120350071279
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Archives of Pharmacal Research 2012 Volume.35 No. 7 p.1279 ~ p.1286
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Attenuation of scopolamine-induced cognitive dysfunction by obovatol
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Choi Dong-Young
Lee Young-Jung Lee Sun-Young Lee Yoot-Mo Lee Hyun-Hee Choi Im-Seop Oh Ki-Wan Han Sang-Bae Nam Sang-Yoon Hong Jin-Tae
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Abstract
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Alzheimer¡¯s disease (AD) is the most prevalent cause of dementia in the elderly people. The disease is pathologically characterized by extracellular deposition of beta-amyloid peptide (A¥â), cholinergic neurodegeneration and elevation of acetylcholine esterase (AChE) activity in the affected regions. In this study, we investigated the effects of obovatol on memory dysfunction, which was caused by scopolamine. Obovatol (0.2, 0.5 and 1 mg/kg for 7 day) attenuated scopolamine (1 mg/kg, i.p.)-induced amnesia in a dose-dependent manner, as revealed by the Morris water maze test and step-through passive avoidance test. Mechanism studies exhibited that obovatol dose-dependently alleviated scopolamine-induced increase in A¥â generation and ¥â-secretase activity in the cortex and hippocampus. Obovatol also attenuated scopolamine-induced rise in AChE activity in the cortex and hippocampus. Obovatol might rescue scopolamine-mediated impaired learning and memory function by attenuating A¥â accumulation and stabilizing cholinergic neurotransmission, which suggests that the natural compound could be a useful agent for the prevention of the development or progression of AD neurodegeneration.
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KEYWORD
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Alzheimer¡¯s disease, Memory, Obovatol, Scopolamine, Secretase, Acetylcholine esterase
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